DBDS
DBDS
CTDS
CTDS
TDDS
TDDS
TFDS
TFDS
CAPSEAL®
CAPSEAL®
BIOXC
BIOXC

MELATHETIC®

CORNEOTHERAPY DELIVERY SYSTEM (CTDS)

NANOVESICLES BY NIOSOMAL 0.1% LUTEIN AND 0.1% ASTAXANTHIN

Natural CTDS technology enables targeted epidermal delivery, enhanced bioavailability, superior light and heat stability, and clear water solubility for high-performance skincare.

  • SKIN REJUVENATION
  • AGE-DEFYING
  • PHOTOAGING PROTECTION
  • SKIN FIRMNESS IMPROVEMENT
Mode of Action

Mode of Action

 

Melatoninergic  Antioxidative System Activation

Melatonin interacts with skin melatonin receptors (MT1/MT2) and activates the Melatoninergic Antioxidative System (MAS). This mechanism enhances antioxidant enzyme activity and helps neutralize hydroxyl radicals, reducing lipid peroxidation, mitochondrial damage, and DNA oxidative stress.

 

ROS Suppression & Anti-Inflammatory Protection

MELATHETIC® reduces ROS-mediated oxidative pathways and suppresses inflammatory signaling pathways associated with skin aging.The in-vitro study demonstrated inhibition of ROS-related mechanisms and suppression of TGF-β1-induced signaling pathways (ERK1/2 and p38).

 

Collagen Stimulation & Skin Remodeling

MELATHETIC® stimulates dermal fibroblast activity and promotes collagen synthesis, supporting improved skin firmness, elasticity, and wrinkle reduction. The in-vitro collagen stimulation assay showed higher collagen synthesis activity compared with Centella asiatica extract, NAG, and L-Ascorbic Acid.

Key Ingredient

Key Ingredient for skin

 

MELATONIN

Activates Melatoninergic Antioxidative System (MAS), scavenges ROS, protects against oxidative damage, and supports cellular defense mechanisms

 

ADENOSINE

Supports collagen production, improves skin elasticity, and promotes skin recovery

Nanovesicle Results

Nanovesicle results

 

168 nm

AVERAGE NANOPARTICLE SIZE 168 nm.

 

95%

ENTRAPMENT EFFICACY

 

-42mV

Zeta-Potential

Benefit of Nano­encapsulation

Benefit of Nanoencapsulation

 

Powered by NANOJET TECHNOLOGY, this sophisticated self-adaptive nano-delivery system delicately stabilizes both actives and guides them deep into the epidermis and dermis through a natural polydextran shell. It delivers exceptional water solubility, enhanced photostability, and prolonged skin absorption, elevating bio-performance for luxurious next-generation skincare formulations.

INCI & Dosage

INCI, Dosage & Recommendation

 

INCI : Melatonin, Adenosine and others (Please contact us to get more information)

 

RECOMMEND DOSAGE : 3- 10%

 

CONCERN : Keep it dry every time after use, To ensure the benefits of encapsulation, this product will not be added into alcohol directly, Suitable pH of formulation should be covered at pH 3.0 – 8.0.

MELATHETIC®

CORNEOTHERAPY DELIVERY SYSTEM (CTDS)

MELATHETIC harnesses advanced NANOJET TECHNOLOGY to enhance bioavailability, photostability, and sustained skin absorption. Encapsulated within natural protective shells, it boosts antioxidant performance and supports skin regeneration, anti-photoaging skincare with improved stability and elevated dermal delivery.

BIO-efficacy & in-vivo results

20X Collagen stimulation assay greater compared to Centella extracts
7X Collagen stimulation assay greater compared to (L)-Ascorbic acid
8X Enhance skin penetration greater than higher than free Melatonin
99% Satisfaction with smoother and plumper skin
95% Satisfaction with improved skin elasticity

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