DBDS
DBDS
CTDS
CTDS
TDDS
TDDS
TFDS
TFDS
CAPSEAL®
CAPSEAL®
BIOXC
BIOXC

CENTEDERM®

TRANSDERMAL DRUG DELIVERY SYSTEM (TDDS)

NANOVESICLES WITH 1% Titrate Extracts of Centella Asiatica (TECA)

An innovation designed for the deepest dermal routine, featuring 100–300 nm lipid bilayer shell technology that is highly compatible with the skin’s stratum corneum. It is engineered for controlled and slow release into the dermal layer, while enhancing bioavailability and bio-efficacy, and offering high stability against light, heat, and high-shear processing.

  • SKIN REPAIR & RECOVERY
  • REDNESS REDUCTION
  • SKIN PURIFICATION
  • SKIN REJUVENATION
Mode of Action

Mode of Action

 

Anti-Inflammatory & Acne Regulation

TECA active compounds help regulate inflammatory pathways. Asiatic Acid provides antioxidant and antibacterial activity, while the synergistic action of Asiaticoside and Madecassic Acid helps reduce inflammatory responses and support acne lesion recovery.

 

Skin Repair & Wound Healing Activation

Supports the skin repair process by promoting cell migration, fibroblast activity, and extracellular matrix formation. This accelerates tissue remodeling and improves skin recovery after inflammatory damage.

 

Collagen Stimulation & Skin Rejuvenation

Stimulate collagen synthesis and support dermal reconstruction, resulting in improved skin strength, elasticity, and overall skin quality.

Key Ingredient

Key Ingredient for skin

 

ASIATICOSIDE

Stimulates fibroblast activity and collagen synthesis while supporting dermal reconstruction.

 

MADECASSIC ACID

Helps regulate inflammatory responses and supports recovery of irritated skin.

 

ASIATIC ACID

Provides antioxidant and antimicrobial activity while helping reduce oxidative stress and acne-related inflammation.

Nanovesicle Results

Nanovesicle results

 

123 nm.

AVERAGE NANOPARTICLE SIZE

 

95%

ENTRAPMENT EFFICACY

 

-42mV

Zeta-Potential

Benefit of Nano­encapsulation

Benefit of Nanoencapsulation

 

Optimized Penetration Dimension with 100 – 300 nm , each niosome is small enough to navigate the intercellular lipid pathway of the stratum corneum while remaining large enough to avoid systemic absorption, maintaining a topical-localized action. It’s enhanced deposition in the viable epidermis and upper dermis and superior bioavailability of both hydrophilic and lipophilic actives through dual-phase distribution.

INCI & Dosage

INCI, Dosage & Recommendation

 

INCI : ASIATICOSIDE, MADECASSIC ACID, ASIATIC ACID, and others (Please contact us to get more information)

 

RECOMMEND DOSAGE : 3-15%

 

CONCERN :
– Incompatible with strong acids, bases, oxidizers and reducers.
– Recommended pH range between 5.0 and 8.0 to avoid conformational changes.

CENTEDERM®

TRANSDERMAL DRUG DELIVERY SYSTEM (TDDS)

TDDS offered the controlled release diffusion with deepest penetration to deliver encapsulated active ingredients through stratum corneum barrier functioned to target cells as Melanocyte, Keratinocyte, Basal layer, Fibroblast and Mast cells.

BIO-efficacy & in-vivo results

184% Anti-inflammatory potency higher than TECA
9X Anti-microbial assay (P.acne) potency higher than Triclosan
3X Enhance skin penetration greater than higher than free TECA
98% Satisfaction with reduced burning sensation, irritation, and itching
95% Satisfaction with reduced appearance of redness and dark spots

SIMILAR PRODUCTS