DBDS
DBDS
CTDS
CTDS
TDDS
TDDS
TFDS
TFDS
CAPSEAL®
CAPSEAL®
BIOXC
BIOXC

NIACAFF®+

TRANSDERMAL DRUG DELIVERY SYSTEM (TDDS)

NANOVESICLES WITH 8% CAFFEINE, 8% NIACINAMIDE, 500 ppm DDBD PEPTIDE

An innovation designed for the deepest dermal routine, featuring 100–300 nm lipid bilayer shell technology that is highly compatible with the skin’s stratum corneum. It is engineered for controlled and slow release into the dermal layer, while enhancing bioavailability and bio-efficacy, and offering high stability against light, heat, and high-shear processing.

  • WRINKLE CORRECTION
  • INFLAMMATION-MODULATING
  • SKIN FIRMING
  • BRIGHTENING
Mode of Action

Mode of Action

 

Neuromuscular Modulation

Synthetic tripeptide that mimics Waglerin-1, a neurotoxin that targets muscle receptors. Dipeptide Diaminobutyroyl Benzylamide Diacetate works by inhibiting muscle contractions in the skin, which are responsible for expression lines and dynamic wrinkles.

 

Action to nAChR

Targets nicotinic acetylcholine receptors (nAChR) on muscle cells. Blocks signal transmission responsible for muscle contraction. Reduces repeated facial movement stress. Visible reduction of dynamic wrinkles

 

Cellular Energy Activation

Purified Caffeine, Inhibits phosphodiesterase (PDE) increases intracellular cAMP. Supports mitochondrial activity and ATP production.Enhances skin vitality and firmness

Key Ingredient

Key Ingredient for skin

 

DDBD PEPTIDE

Mimics Waglerin-1 activity by targeting nAChR receptors and reducing muscle contraction signals associated with dynamic wrinkles.

 

PURIFIED CAFFEINE

Inhibits PDE to increase cAMP, stimulates cellular metabolism, enhances microcirculation, and protects against oxidative stress.

 

NIACINAMIDE

Enhances ceramide synthesis, reduces inflammatory signaling, inhibits melanosome transfer, and supports NAD⁺ metabolism

Nanovesicle Results

Nanovesicle results

 

132 nm.

AVERAGE NANOPARTICLE SIZE

 

95%

ENTRAPMENT EFFICACY

 

-50 mV

Zeta-Potential

Benefit of Nano­encapsulation

Benefit of Nanoencapsulation

 

Optimized Penetration Dimension with 100 – 300 nm , each niosome is small enough to navigate the intercellular lipid pathway of the stratum corneum while remaining large enough to avoid systemic absorption, maintaining a topical-localized action. It’s enhanced deposition in the viable epidermis and upper dermis and superior bioavailability of both hydrophilic and lipophilic actives through dual-phase distribution.

INCI & Dosage

INCI, Dosage & Recommendation

INCI : CAFFEINE, NIACINAMIDE, DDBD Peptide and others (Please contact us to get more information)
RECOMMEND DOSAGE : 2-10%
CONCERN :
– Incompatible with strong acids, bases, oxidizers and reducers.
– Recommended pH range between 5.0 and 8.0 to avoid conformational changes.

NIACAFF®+

TRANSDERMAL DRUG DELIVERY SYSTEM (TDDS)

TDDS offered the controlled release diffusion with deepest penetration to deliver encapsulated active ingredients through stratum corneum barrier functioned to target cells as Melanocyte, Keratinocyte, Basal layer, Fibroblast and Mast cells.

BIO-efficacy & in-vivo results

8X SOD assay greater than free caffeine and Melon SOD
6X Anti-collagenase greater than free caffeine and Melon SOD
8.2X Enhance skin penetration greater than higher than free DDBD peptide
98% Satisfaction with improved facial wrinkle appearance
96% Satisfaction with improved skin smoothness

SIMILAR PRODUCTS